Valery A. Chereshnev


Address
13 Goleva, Perm 614081, Russia
Institute of Ecology and Genetics of Microorganisms
at the Ural Branch of the Russian Academy of Sciences
 
Phone, Fax, e-mail
tel: +7-(342)-280-74-42, +7-(342)-280-75-60, fax: +7-(342)-280-92-11, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it., This email address is being protected from spambots. You need JavaScript enabled to view it.
 
Date of Birth
24.10.1944
 
 
Educational Background
Perm State Medical Institute, Speciality “Medical Practice” 1968.
Post-graduate Study. Perm State Medical Institute. 1968-1970.
Dissertation “On the role of microbial cell and macroorganism in the mechanism of early phagocyte reaction development to the injection of TAB vaccine” at the Department of Pathological Physiology of Perm State Medical Institute. 1972.
Postdoctoral applicant, Perm State Medical Institute, 1976-1983.
Awarded the degree of Doctor of Medical Sciences for the dissertation “Closed chest injury in combination with gamma irradiation (clinical characteristics, pathogenesis, treatment, medical protection)” at Perm State Medical Academy, 1984.
 
Academic Degrees and Titles
Candidate of Medicine. Perm State Medical Institute. 1972.
Doctor of Medical Sciences. Perm State Medical Institute. 1984.
Corresponding Member of the Russian Academy of Sciences. 1990.
Professor. 1991.
Soros Fund Professor. 1997-2001.
Active Member of the Russian Academy of Sciences. 1997.
Active Member of the Russian Academy of Medical Sciences. 2005.
 
Stages of Professional Career
Assistant Lecturer, Senior Lecturer, Reader. Perm State Medical Institute, 1970-1988.
Head of Fundamental Research Laboratory, Perm State Medical Institute. 1970-1988.
Head of Central Scientific Research Laboratory. Perm State Medical Institute. 1983-1987.
Director of the Institute of Ecology and Genetics of Microorganisms at the Ural Branch of the Russian Academy of Sciences. 1988-2003.
Head of Department of Microbiology and Immunology, Faculty of Biology, Perm State University. Since 1990 till present date.
Chairman of the Ural Branch of the Russian Academy of Sciences. 1999-2008.
Vice-President of the Russian Academy of Sciences. 1999-2001.
Member of Presidium of the Russian Academy of Sciences. 1999 – till present date.
Member of Presidium of the Ural Branch of the Russian Academy of Sciences. 1997 – till present date.
Organiser and Head of Perm Institute of Ecology and Genetics of Microorganisms’ branch of the Ural Branch of the Russian Academy of Sciences (Yekaterinburg). 2000-2003.
Director of Institute of Immunology and Physiology of the Ural branch of the Russian Academy of Sciences (Yekaterinburg). 2003- till present date.
Member of the State Duma of the Russian Federation. Chairman of the Committee on Science and High Technologies at the State Duma of the 5th Call Federal Assembly of the Russian Federation. Since 2007 till present date.
 
Membership in Scientific Councils, other State and Public Associations
Member of Scientific Council of the Institute of Ecology and Genetics of Microorganisms at the Ural Branch of the Russian Academy of Sciences.
Member of Dissertation Council DM 004.019.01 at the Institute of Ecology and Genetics of Microorganisms at the Ural Branch of the Russian Academy of Sciences.
Member of Dissertation Council D 004.027.01 of the Institute of Immunology and Physiology at the Ural Branch of the Russian Academy of Sciences.
Chairman of Committee for Science and Knowledge Intensive Technologies at the State Duma of the Russian Federation.
Member of the Russian Federation Expert Council of the Higher Attestation Commission in Biological Sciences.
Member of Scientific Advisory Council at the Foundation for the Development of the Center of Development and Commercialization of High Technologies in Skolkovo.
Expert in European Consortium “EURO-Net”, expert at European Association for AIDS and tuberculosis.
President of the Russian and Chairman of the Ural Societies of Immunologists.
Member of expert commissions for awarding Demidov Prize, juryman for awarding the Russian Independent Prize “Triumph”.
Member of Joint Scientific Council in Biological Sciences at the Ural Branch of the Russian Academy of Sciences.
Chairman of Guardian Council at Perm Heart Institute.
 
Leader of Research Projects
Federal Target Research and Development Programme “Research and development in the priority scientific and technological fields for 2002-2007”. Priority field “Living Systems”. Program arrangement 1.12 “Development of the leading scientific school of thought as a basis for generation knowledge and training of scientific-pedagogical specialists of higher qualification”. (XII turn – Schools of Thought). National Contract of June, 9th, 2006, No. 02.445.11.7378. 2006. Subject: Novel preparations of bioactive compounds of microbial origin as the basis for the designing promising medicinal agents.
 
Federal Target Research and Development Programme “Research and development in the priority scientific and technological complex in Russia for 2007-2012”. Lot 1. Measures to carry out ptoblem-oriented research studies to create scientific-technical basis in the field of living systems using crucial technology “Biocatalytic, biosynthetic, biosensor technologies”. Priority field “Living Systems”. National Contract of August, 1st, 2008. No. 02.512.12.0003. 2008. Subject: Production of bioactive compounds of bacterial origin as promising for creating novel medicinal agents.
 
Grant of Russian Federation President to support leading schools of thought of the Russian Federation. Project ST-1103.2006.4. Novel preparations of bioactive compounds of microbial origin as the basis for designing promising medicinal agents. 2006-2007.
 
Grant of Russian Federation President to support leading schools of thought of the Russian Federation. Project ST-4112.2008.4. Development of bioactive compounds of bacterial origin as promising for the designing novel medicinal agents. 2008-2009.
 
Grant of Russian Federation President to support leading schools of thought of the Russian Federation. Project ST-64403.2010.4. Bioactive compounds of bacterial origin as the basis for creating novel medicinal agents. 2010-2011.
 
Federal Target Research and Development Programme “Research and development in the priority scientific and technological fields in 2010”. Development of the schools of thought system as the basis for generating of knowledge and for preparation of the scientific and pedagogical specialists of higher qualification.
 
Russian Academy of Sciences Presidium Programme "Fundamental Sciences – to Medicine".
 
Current Scientific Activities
The key postulates of immunophysiology as a new scientific trend have been formulated and validated. Immunophysiology recognizes the immune system, along with nervous and endocrine ones, as a regulator of physiological functions in the normal state and during the body adaptation to extreme factors. The change in the functional state of the immune system particular components under the influence of factors which do not lead to antigenic shifts has been demonstrated. The dependence links between mast cells and thromobocytosis, labrocytes and eosinophil growth have been discovered. The role of mast cells (heparin, histamine, glycosaminoglycans) in regulation of the body adaptive reactions has been demonstrated.
 
The principles of immune correction in various immune deficiency states caused by pathological processes, including inflammatory, autoimmune and oncologic ones, have been developed in the experiment and in clinical conditions. More than 10 Russian immune regulators, including angiotensin converting enzyme, polyoxidonium and myelopidum have been studied and their efficiency as a part of complex therapy has been proved.
 
Scientific-methodological basis for creation ecologically friendly technology of producing bioactive compounds based on non-pathogenic bacteria has been elaborated. Mechanisms of biosynthesis regulation have been analyzed; preparations from bacterial glycolipids and cationic peptides have been produced that possess high antibiotic and immune modulating activity. Results of thorough investigation of molecular-cellular mechanisms of immunomodulating and antimicrobial action of bacterial glycolipids and peptides favour the broadening of fundamental knowledge of interactions between microorganisms, their vital activity products and human immune system.
 
Valery A. Chereshnev has supervised 26 Candidates and 40 Doctors of Sciences.
 
Academic and other Awards
Medal “For Work Distinction”. 1981.
Gold Medal of All-Union Exhibition of Achievements of National Economy of the USSR. 1981.
Order of Friendship. 1998.
Gold Badge “For Merit for the City of Perm”. 1999.
P.L. Kapitza, (2001, 2003) I.P. Pavlov (2003), A.D. Speransky (2003), I.I. Mechnikov (2002) Silver Medals.
V.V. Pashutin Medal of the Russian Academy of Medical Sciences. 2003.
V.V. Parin Prize from the Ural Branch of the Russian Academy of Sciences. 2003.
Prize from the Ural Branch of the Russian Academy of Sciences.2004.
Order “For Merits for the Fatherland” IV Class. 2004.
P. Ehrlich and R. Virchow Gold Medals of the European Academy of Natural Sciences (Hanover). 2004.
Prize from the Russian Academy of Sciences for perfect work in science popularization. 2006.
Stroganov’s Prize from Perm Fraternity. 2007.
V.B. Parin Prize from the Russian Academy of Medical Sciences. 2008.
S.S. Schwartz Prize from the Ural Branch of the Russian Academy of Sciences. 2010.
Gold Medal Sign from UNESCO. 2010.
Silver Medal of UNESCO “AVICENNA (Ibn-Sina) – 980-1037”, passed by UN Committee of the Issues of Education, Science and Culture. 2011.
The winner of the leading scientific schools contest “Development of bioactive compounds of bacterial origin as promising for creating new medicinal products”. 2005-2008.
 
Total Number of Publications
More than 500 scientific articles,
30 monographs,
14 books,
4 course books,
13 school-books,
2 inventions,
36 patents.
 
Selected Publications
1. Chereshnev V.A., Rybina N.V., Beikin Ya.B., Oboskalova T.Ya. Immunologic and genetic factors of reproductive function impairment. Yekaterinburg: Ural Branch of the Russian Academy of Sciences Publication, 2005. 176 p. (In Russian)
2. Chereshnev V.A., Yushkov B.G., Tyumentseva N.V. et al. New approaches towards production of auto prostheses for angioplasty // Doklady Akademii Nauk. 2006. Vol. 408, No. 1-6. P. 711-713. (In Russian)
3. Chereshnev V.A., Gamburtsev A.G., Breus T.K. Humans and their three environments // Herald of the Russian Academy of Sciences. 2007. Vol. 77, No. 7. P. 618-627. (In Russian)
4. Sibiryak S.V., Khaidukov S.V., Zurochka A.V., Chereshnev V.A. Estimation of apoptosis in immunological research. Yekaterinburg, 2008. 60 p. (In Russian)
5. Gusev E. Ju., Chereshnev V.A., Zhuravlyova et al. Variants of chronic systemic inflammation progression //  Medical Immunology. 2009. Vol.11, No. 2-3. P. 131-140 (in Russian)
6. Human ecology in changing World /Ed. RAS and RAMS academician V.A. Chereshnev – Yekaterinburg: Ural Branch of the Russian Academy of Sciences. 2006. 570 p. (in Russian)
7. Chereshnev V.A., Gein S.V., Baeva T.A., Galkina T.V., Kuyukina M.S., Ivshina I.B. Modulation of cytokine secretion and oxidative metabolism of innate immunity effectors under the effect of Rhodococcus biosurfactant // Bulletin of Experimental Biology and Medicine. 2010. No. 6. P. 673-677.
8. Chereshnev V.A., Chereshneva M.V. Immunological mechanisms of local inflammation // Medical Immunology. 2011. Vol. 13, No. 6. P.557-568.
9. Chereshnev V.A., Shilov Ju.I., Chereshneva M.V.  et al. Experimental models for pathological states: course book / Perm State University. Perm. 2011. 267 p.
10. Bocharov G., Quiel J., Luzyanina T., Alon H., Chiglintcev E., Chereshnev V., Meier-Schellersheim M., Paul W., Grossman Z. Feedback regulation of proliferation vs. differentiation rates explains the dependence of CD4 T-cell expansion on precursor number // Proc. Natl. Ac. Sc. USA. 2011. Vol.108, No 8.  P. 3318-3323.
11. Bocharov G., Danilov A., Vassilevski Yu,. Marchuk G.I., Chereshnev V.A., Ludewig B. Reaction diffusion modeling of interferon distribution in secondary lymphoid organs // In: Mathematical modeling of natural phenomena. 2011. Vol. 6, No 7. P. 13-26.
12. Alvarez M.A., Bocharov G., Chereshnev V., Karamov E. Research Priorities for HIV/M. Tuberculosis Co-Infection // The Open Infectious Diseases Journal. 2011. Vol. 5. P. 14-20.
13. Gein S.V., Kuyukina M.S., Ivshina I.B., Baeva T.A., Chereshnev V.A. In vitro cytokine stimulation assay for glycolipid biosurfactant from Rhodococcus ruber: role of monocyte adhesion // Cytotechnology. 2011. DOI: 10.1007/s10616-011-9384-3.

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