Vitaly A. Demakov


Address
15 Bukireva, Perm 614990, Russia
Perm State University
Faculty of Biological Sciences
Department of Microbiology and Immunology
 
Phone, fax, e-mail
tel: +7-(342)-280-74-42, fax: +7-(342)-280-92-11, e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.
 
Date of Birth
23.10.1946
 
Educational Background
Faculty of Sanitation and Hygiene, Perm State Medical Institute, 1971.
Post-graduate study. Perm State Medical Institute, 1974.
Doctorate Course. Doctoral Graduand, 1999.
 
Academic Degrees and Titles
Candidate of Medicine, 1975, Department of Common Hygiene, Perm State Medical Institute.
Senior Research Fellow, 1990.
Doctor of Medicine, 1999, Perm State Medical Institute.
Professor, 1999.
Corresponding Member of the Russian Academy of Sciences (Biology Department), 2008.
 
Stages of Professional Career
Assistant Lecturer, Perm State Medical Institute. 1974-1978.
Senior Research Fellow, the Institute of Ecology and Genetics of Microorganisms of Ural Branch of the Russian Academy of Sciences. 1978.
Head of laboratory, the Institute of Ecology and Genetics of Microorganisms of Ural Branch of the Russian Academy of Sciences. 1989.
Deputy Director for Science, the Institute of Ecology and Genetics of Microorganisms of Ural Branch of the Russian Academy of Sciences. 1997.
Director, the Institute of Ecology and Genetics of Microorganisms of Ural Branch of the Russian Academy of Sciences. 2003.
Professor, Department of Microbiology and Immunology, Faculty of Biological Sciences, Perm State University. 2005 till present.
 
Membership in Scientific Councils and other State and Public Associations
Chairman of Scientific Council at the Institute of Ecology and Genetics of Microorganisms of Ural Branch of the Russian Academy of Sciences.
Vice-Chairman of Dissertation Council at the Institute of Ecology and Genetics of Microorganisms of Ural Branch of the Russian Academy of Sciences.
 
Management of Research Projects
Grants of the Russian Foundation for Fundamental Research:
2006 (06-04-03023б, 06-04-01862eb)
2007 (07-04-97617, 07-04-96071, 07-04-0527, 07-04-97407, 07-04-06112)
2008 (07-04-97617, 07-04-96071, 07-04-0527, 08-04-67101г, 08-04-05020б, 08-04-99509рб, 08-04-01801eb)
2009 (07-04-97617, 07-04-96071, 07-04-0527).
 
Programmes of the General Committee of the Russian Academy of Sciences:
• “Molecular and Cell Biology”, “Fundamental basis of reproduction and optimization of gene pool of plants, animals and humans”, “Biodiversity and genetics of gene pools”, “Fundamental basis of bioresources’ management”, 2004-2011.
• Integration programme of fundamental research carried out jointly with the Siberian Branch of the Russian Academy of Sciences, 2004-2009.
• “Development of biocatalytic technologies of synthesis of organic acids and enantiomerically pure compounds for polymeric chemistry, medicine and ecological biotechnology on the basis of producer microorganisms selected from natural and anthropogenically inflected soils”.
• “Study of metabolism of organic compounds: carboxylic acids derived from the bacteria from natural and anthropogenically inflected environment of midland Russia with the assessment of their biotechnological potential”.
 
Current Research Activities
• Research of biochemical and genetic systems of transformation of organic compounds of bacteria prospective for biotechnology.
• Selection, chemical mutagenesis and genetic construction of microbial strains for biotransformation, biocatalysis and biodegradation of organic compounds.
• Development of biocatalytic technologies of synthesis of organic acids, amides, ethers and enantiomerically pure compounds for polymeric chemistry, medicine and ecological biotechnology on the basis of producer microorganisms selected from natural and anthropogenically inflected soils.
• Study of the processes of metabolism and biotransformation of derivates of carboxylic acids: nitriles, amides, complex ethers, aliphatic and aromatic acids; aromatic compounds: derivates of benzene, phenol, pyridine, quinoline, acridine and sulfur-containing aromatic compounds.
• Research of the ferments of metabolism of organic compounds: nitrile hydrase, nitrilase, amidase, carboxylesterase and aldoxime dehydratase.
• Study of the impact of various forms of immobilization on biocatalytic systems and biocatalysis.
• Research of plasmids and factors of resistance for the construction of vectors of cloning.
• Study of the metabolic fates of decomposing of mono- and polyaromatic compounds and their halogenated derivatives and the characteristics of key enzymes of transformation of these compounds in active bacteria-destructors.
 
Academic and other Awards
Medal of the Order "For Being Useful to the Fatherland", II Degree. 2009.
Certificates of Merit of the Russian Academy of Sciences and the Russian Academy of Sciences Trade Union, Ural Branch of the Russian Academy of Sciences and the Perm Krai Government.
 
Total Number of Publications – 245.
105 scientific articles
4 monographs.
 
Selected Publications
1. Demakov V.A., Maksimov A.Y. Catalytic properties of nitrile hydrase immobilized on aluminum oxide and carboniferous adsorbents // Applied biochemistry and microbiology. 2010. Vol. 46. No. 4. P. 16 - 42. (in Russian)
2. Demakov V.A., Maksimova Y.G., Maksimov A.Y. Immobilization of microbial cells: biotechnological aspects // Biotechnology. 2008. No.2. P. 30-45. (in Russian)
3. Maksimov A.Y., Maksimova Y.G., Kuznetsova M.V., Olontsev V.F., Demakov V.A. Immobilization on carboniferous sorbents the Rhodococcus ruber gt1 strain with nitrile hydrase activity // Applied biochemistry and microbiology. 2007. Vol. 43. No. 2. P. 193 - 198. (in Russian)
4. Demakov V.A., Maksimov A.Y., Kuznetsova M.V.,Ovetshkina G.V., Remezovskaya N.B.,  Maksimova Y.G. Biological diversity of nitrile metabolizing bacteria of anthropogenically inflected soils in the Perm Krai // Ecology. 2007. No. 3. P. 185-190. (in Russian)
5. Maksimov A.Y., Kuznetsova M.V.,Ovetshkina G.V., Kozlov S.V., Maksimova Y.G., Demakov V.A. Impact of nitriles and amides on growth and nitrile hydrase activity of Rhodococcus sp. gt1 strain // Applied biochemistry and microbiology. 2003. Vol. 39. No. 1. P. 63 - 68. (in Russian)
 
Patents
1. Pat. 2352635 Russian Federation. Production process of immobilized biocatalyst and aqueous solutions of amides using this biocatalyst / Maksimov A.Y., Demakov V.A., Maksimova Y.G., Olontsev V.F. Priority on 22.03.2007. Reg. in State Utility Invention Registry 20.04.2009.
2. Pat. 2262531 Russian Federation. Rhodococcus ruber strain as a decomposer of polychlorinated biphenyls / Plotnikova Y.G., Rybkina D.O., Demakov V.A. Priority on 02.12.2003. Reg. in State Utility Invention Registry 20.10.2005.
3. Pat. 2223316 Russian Federation. Rhodococcus ruber strain as a producer of nitrile hydrase / Demakov V.A., Maksimov A.Y., Alikin V.N., Kuznetsova M.V., Ovetshkina G.V., Budnikov V.I., Fedshenko V.N., Fedshenko N.N., Kuzmitsky G.E., Tshereshnev V.A. Reg. in State Utility Invention Registry 10.02.2004.
4. Pat. 2196822 Russian Federation. Rhodococcus erythropolis strain as a producer of nitrile hydratase / Demakov V.A., Maksimov A.Y., Kuznetsova M.V., Ovetshkina, G.V., Kozlov S.V., Remezovskaya N.B., Maksimova Y.G. Priority on 25.07.2001. Reg. in State Utility Invention Registry 18.12.2003.

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